Di Renzo GC, Conry JA, Blake J, DeFrancesco MS, DeNicola N, Martin JN Jr, et al. Worldwide Federation of Gynecology and Obstetrics opinion on reproductive well being impacts of publicity to poisonous environmental chemical substances. Int J Gynaecol Obstet. 2015;131(3):219–25.
Grandjean P, Landrigan PJ. Neurobehavioural results of developmental toxicity. Lancet Neurol. 2014;13(3):330–8.
Mendes S, Timoteo-Ferreira F, Almeida H, Silva E. New insights into the method of placentation and the function of oxidative uterine microenvironment. Oxid Med Cell Longev. 2019;2019.
Solano ME. Decidual immune cells: guardians of human pregnancies. Finest PractRes Clin Obstetr Gynaecol. 2019;60:3–16.
Aplin JD, Myers JE, Timms Ok, Westwood M. Monitoring placental improvement in well being and illness. Nat critiques Endocrinol. 2020;16(9):479–94.
Myllynen P, Pasanen M, Pelkonen O. Human placenta: a human organ for developmental toxicology analysis and biomonitoring. Placenta. 2005;26(5):361–71.
Mackevica A, Foss Hansen S. Launch of nanomaterials from strong nanocomposites and shopper publicity evaluation – a forward-looking assessment. Nanotoxicology. 2016;10(6):641–53.
Kabir E, Kumar V, Kim Ok-H, Yip ACK, Sohn JR. Environmental impacts of nanomaterials. J Environ Handle. 2018;225:261–71.
Pelin M, Sosa S, Prato M, Tubaro A. Occupational publicity to graphene primarily based nanomaterials: danger evaluation. Nanoscale. 2018;10(34):15894–903.
Zhou Y, Ji J, Chen C, Hong F. Retardation of Axonal and Dendritic Outgrowth Is Related to the MAPK Signaling Pathway in Offspring Mice Following Maternal Publicity to Nanosized Titanium Dioxide. J Agric Meals Chem. 2019;67(9):2709–15.
Zhang S, Meng P, Cheng S, Jiang X, Zhang J, Qin X, et al. Being pregnant publicity to carbon black nanoparticles induced neurobehavioral deficits which can be related to altered m(6)A modification in offspring. Neurotoxicology. 2020;81:40–50.
Naguib M, Kurtoglu M, Presser V, Lu J, Niu J, Heon M, et al. Two-dimensional nanocrystals produced by exfoliation of Ti3AlC2. Adv Mater. 2011;23(37):4248–53.
George SM, Kandasubramanian B. Developments in MXene-Polymer composites for numerous biomedical purposes. Ceram Int. 2020;46(7):8522–35.
Chen Ok, Qiu N, Deng Q, Kang MH, Kim HE. Cytocompatibility of Ti3AlC2, Ti3SiC2, and Ti2AlN: in vitro assessments and first-principles calculations. ACS Biomater Sci Eng. 2017;3(10):2293.
Jastrzębska AM, Szuplewska A, Wojciechowski T, Chudy M, Ziemkowska W, Chlubny L, et al. In vitro research on cytotoxicity of delaminated Ti(3)C(2) MXene. J Hazard Mater. 2017;339:1–8.
Sui B, Liu X, Solar J. Biodistribution, inter-/intra-cellular localization and respiratory dysfunction induced by Ti3C2 nanosheets: Involvement of surfactant protein down-regulation in alveolar epithelial cells. J Hazard Mater. 2020;402:123562.
Walejko JM, Chelliah A, Keller-Wooden M, Gregg A, Edison AS. World metabolomics of the placenta reveals distinct metabolic profiles between maternal and fetal placental tissues following supply in non-labored girls. Metabolites. 2018;8(1):10.
Zhang RY, Tu JB, Ran RT, Zhang WX, Tan Q, Tang P, et al. Utilizing the metabolome to grasp the mechanisms linking power arsenic publicity to microglia activation, and studying and reminiscence impairment. Neurotox Res. 2021;39(3):720–39.
Hudson KM, Shiver E, Yu JS, Mehta S, Jima DD, Kane MA, et al. Transcriptomic, proteomic, and metabolomic analyses establish candidate pathways linking maternal cadmium publicity to altered neurodevelopment and habits. Sci Rep. 2021;11(1):16302.
Rossant J, Cross JC. Placental improvement: classes from mouse mutants. Nat Rev Genet. 2001;2(7):538–48.
Basak S, Mallick R, Duttaroy AK. Maternal docosahexaenoic acid standing throughout being pregnant and its affect on toddler neurodevelopment. Vitamins. 2020;12(12):3615.
Lewis RM, Wadsack C, Desoye G. Placental fatty acid switch. Curr Opin Clin Nutr Metab Care. 2018;21(2):78–82.
Ghidiu M, Lukatskaya MR, Zhao MQ, Gogotsi Y, Barsoum MW. Conductive two-dimensional titanium carbide ‘clay’ with excessive volumetric capacitance. Nature. 2014;516(7529):78–81.
Lin H, Wang X, Yu L, Chen Y, Shi JJNL. Two-dimensional ultrathin MXene ceramic nanosheets for photothermal conversion. Nano Lett. 2017;17(1):384.
Good KF, Aggio RB, Van Houtte JR, Villas-Bôas SG. Analytical platform for metabolome evaluation of microbial cells utilizing methyl chloroformate derivatization adopted by gasoline chromatography–mass spectrometry. Nat Protoc. 2010;5(10):1709–29.
Yang Y, Wang L, Chen C, Qi H, Baker PN, Liu X, et al. Metabolic modifications of maternal uterine fluid, uterus, and plasma through the peri-implantation interval of early being pregnant in mice. Reprod Sci (Thousand Oaks Calif). 2020;27(2):488–502.
Cao Ok, Rohart F, Gonzalez I, Coquery J, Yao FZ, Liquet B. mixOmics: Omics Information Integration Undertaking. 2017.
Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC, et al. pROC: an open-source package deal for R and S plus to investigate and evaluate ROC curves. BMC Bioinformatics. 2011;12:77.
Fong GH, Rossant J, Gertsenstein M, Breitman ML. Position of the Flt-1 receptor tyrosine kinase in regulating the meeting of vascular endothelium. Nature. 1995;376(6535):66–70.
Ying Y, Zhao GQ. Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell technology within the mouse. Dev Biol. 2001;232(2):484–92.
Zhong H, Geng Y, Chen J, Gao R, Yu C, Yang Z, et al. Maternal publicity to CeO(2)NPs throughout early being pregnant impairs being pregnant by inducing placental abnormalities. J Hazard Mater. 2020;389:121830.
Wang Z, Zhang C, Liu X, Huang F, Wang Z, Yan B. Oral consumption of ZrO2 nanoparticles by pregnant mice leads to nanoparticles’ deposition in fetal brains. Ecotoxicol Environ Saf. 2020;202:110884.
Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Impact of in utero and early-life situations on grownup well being and illness. N Engl J Med. 2008;359(1):61–73.
Murphy VE, Smith R, Giles WB, Clifton VL. Endocrine regulation of human fetal development: the function of the mom, placenta, and fetus. Endocr Rev. 2006;27(2):141–69.
Higashisaka Ok, Nakashima A, Iwahara Y, Aoki A, Nakayama M, Yanagihara I, et al. Neutrophil depletion exacerbates being pregnant issues, together with placental injury, induced by silica nanoparticles in mice. Entrance Immunol. 2018;9:1850.
Xu S, Zhang Z, Chu M. Lengthy-term toxicity of lowered graphene oxide nanosheets: results on feminine mouse reproductive capacity and offspring improvement. Biomaterials. 2015;54:188–200.
Zhang Q, Ding Y, He Ok, Li H, Gao F, Moehling TJ, et al. Publicity to alumina nanoparticles in feminine mice throughout being pregnant induces neurodevelopmental toxicity within the offspring. Entrance Pharmacol. 2018;9:253.
Wang Z, Zhang C, Huang F, Liu X, Wang Z, Yan B. Breakthrough of ZrO2 nanoparticles into fetal brains is dependent upon developmental stage of maternal placental barrier and fetal blood–brain-barrier. J Hazard Mater. 2021;402:123563.
Su J, Duan X, Qiu Y, Zhou L, Zhang H, Gao M, et al. Being pregnant publicity of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that aren’t vital postnatally however emerge in maturity of offspring. J Nanobiotechnol. 2021;19(1):234.
Zhang Y, Xu B, Yao M, Dong T, Mao Z, Cling B, et al. Titanium dioxide nanoparticles induce proteostasis disruption and autophagy in human trophoblast cells. Chemico-Biol Work together. 2018;296:124–33.
Notter T, Aengenheister L, Weber-Stadlbauer U, Naegeli H, Wick P, Meyer U, et al. Prenatal publicity to TiO2 nanoparticles in mice causes behavioral deficits with relevance to autism spectrum dysfunction and past. Transl Psychiatry. 2018;8(1):193.
Copp AJ, Greene ND, Murdoch JN. The genetic foundation of mammalian neurulation. Nat Rev Genet. 2003;4(10):784–93.
Mao J, Jain A, Denslow ND, Nouri MZ, Chen S, Wang T, et al. Bisphenol A and bisphenol S disruptions of the mouse placenta and potential results on the placenta-brain axis. Proc Natl Acad Sci USA. 2020;117(9):4642–52.
Behura SK, Kelleher AM, Spencer TE. Proof for useful interactions between the placenta and mind in pregnant mice. FASEB. 2019;33(3):4261–72.
Watson ED, Cross JC. Improvement of buildings and transport features within the mouse placenta. Physiology (Bethesda). 2005;20:180–93.
Hemberger M, Hanna CW, Dean W. Mechanisms of early placental improvement in mouse and people. Nat Rev Genet. 2020;21(1):27–43.
Pardi G, Marconi AM, Cetin I. Placental-fetal interrelationship in IUGR fetuses—a assessment. Placenta. 2002;23(Suppl A):136–41.
Arumugasaamy N, Rock KD, Kuo CY, Bale TL, Fisher JP. Microphysiological techniques of the placental barrier. Adv Drug Deliv Rev. 2020;161–162:161–75.
Barjaktarovic M, Korevaar TIM, Jaddoe VWV, de Rijke YB, Peeters RP, Steegers EAP. Human chorionic gonadotropin and danger of pre-eclampsia: potential population-based cohort research. Ultrasound Obstet Gynecol. 2019;54(4):477–83.
Burton GJ, Redman CW, Roberts JM, Moffett A. Pre-eclampsia: pathophysiology and medical implications. BMJ (Clin Res Ed). 2019;366:l2381.
Wang F, Zhang L, Zhang F, Wang J, Wang Y, Man D. First trimester serum PIGF is related to placenta accreta. Placenta. 2020;101:39–44.
Yuan P, Hu XG, Zhou QX. The nanomaterial-induced bystander results reprogrammed macrophage immune operate and metabolic profile. Nanotoxicology. 2020;14(8):1137–55.
Cui L, Wang X, Solar BB, Xia T, Hu S. Predictive metabolomic signatures for security evaluation of steel oxide nanoparticles. ACS Nano. 2019;13(11):13065–82.
McIntyre KR, Hayward CE, Sibley CP, Greenwood SL, Dilworth MR. Proof of adaptation of maternofetal transport of glutamine relative to placental measurement in regular mice, and in these with fetal development restriction. J Physiol. 2019;597(19):4975–90.
Fisher SE, Karl PI. Histidine switch throughout the human placenta: traits within the remoted perfused human placenta and the impact of ethanol. Placenta. 1990;11(2):157–65.
Haggarty P. Fatty acid provide to the human fetus. Annu Rev Nutr. 2010;30:237–55.
Cinelli G, Fabrizi M, Rava L, Signore F, Vernocchi P, Semeraro M, et al. Affiliation between maternal and foetal erythrocyte fatty acid profiles and start weight. Vitamins. 2018;10(4):402.
Hurtado JA, Iznaola C, Peña M, Ruíz J, Peña-Quintana L, Kajarabille N, et al. Results of maternal Ω-3 supplementation on fatty acids and on visible and cognitive improvement. J Pediatr Gastroenterol Nutr. 2015;61(4):472–80.
Basak S, Vilasagaram S, Duttaroy AK. Maternal dietary deficiency of n-3 fatty acids impacts metabolic and epigenetic phenotypes of the creating fetus. Prostaglandins Leukot Essent Fatty Acids. 2020;158:102109.
Whalley LJ, Fox HC, Wahle KW, Starr JM, Deary IJ. Cognitive getting old, childhood intelligence, and the usage of meals dietary supplements: doable involvement of n-3 fatty acids. Am J Clin Nutr. 2004;80(6):1650–7.
Helland IB, Smith L, Saarem Ok, Saugstad OD, Drevon CA. Maternal supplementation with very-long-chain n-3 fatty acids throughout being pregnant and lactation augments youngsters’s IQ at 4 years of age. Pediatrics. 2003;111(1).
Reinecke CJ, Koekemoer G, van der Westhuizen FH, Louw R, Lindeque JZ, Mienie LJ, et al. Metabolomics of urinary natural acids in respiratory chain deficiencies in youngsters. Metabolomics. 2012;8(2):264–83.
Gal JS, Morozov YM, Ayoub AE, Chatterjee M, Rakic P, Haydar TF. Molecular and morphological heterogeneity of neural precursors within the mouse neocortical proliferative zones. J Neurosci 2006;26(3):1045–56.
Rosenfeld CS. The placenta-brain-axis. J Neurosci Res. 2021;99(1):271–83.
Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ, et al. Microglia induce motor neuron demise by way of the classical NF-κB pathway in amyotrophic lateral sclerosis. Neuron. 2014;81(5):1009–23.
Lee JA, Damianov A, Lin CH, Fontes M, Parikshak NN, Anderson ES, et al. Cytoplasmic Rbfox1 regulates the expression of synaptic and autism-related genes. Neuron. 2016;89(1):113–28.